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Eukaryotic Initiation Factor 4 A

INTRODUCTION

The mechanisms governing the basic subsistence of eukaryotic cells are immensely complex; it is unsurprising therefore that regulation occurs at a number of stages of protein synthesis - the regulation of translation has become a well studied field (Gingras et al 1999). Human translational control is of increasing research interest as it has connotations in a range of diseases (Hollams et al 2002). Orthologues of many of the factors involved in human translation are shared by a range of eukaryotic organisms; some of which are used as model systems for the investigation of translation initiation, for example: sea urchin eggs and rabbit reticulocytes (Li et al 2001). Monod and Jacob were among the first to propose that "the synthesis of individual proteins may be provoked or suppressed within a cell, under the influence of specific external agents, and the relative rates at which different proteins may be profoundly altered, depending upon external conditions" (Monod & Jacob 1961). Almost half a century after the flurry of postulations arising from the revelation of the central dogma of molecular biology, of which the preceding supposition by Monod and Jacob is an example; contemporary researchers still have much to learn about the modulation of genetic expression. Synthesis of protein from mature messenger RNA in […]

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